Compound Overview

GLP1-S is a modified 31-amino-acid glucagon-like peptide-1 analogue. Reported structural features for semaglutide include an Aib substitution at position 8, an Arg substitution at position 34, and derivatization at Lys26.

This material is supplied as a laboratory research reagent intended for controlled experimental environments for in vitro receptor-binding studies, functional cell-based assay work, albumin-affinity characterization, and structural studies of GLP-1 receptor engagement.

Molecular Information

Compound Type: Peptide
Sequence: HXEGTFTSDV SSYLEGQAAK EFIAWLVRGR G
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.58 g/mol
CAS Number: 910463-68-2
Purity: 98.90%

Research Applications

Published semaglutide research includes receptor-binding, functional potency, albumin-affinity, and structural studies focused on GLP-1 receptor engagement and the behavior of its modified peptide scaffold.

In vitro GLP-1 receptor binding measurements in human GLP-1R-expressing cell systems
In vitro functional potency assays in GLP-1R reporter cell systems
Comparative structure-activity studies of Lys26-derivatized GLP-1 analogue constructs containing the semaglutide backbone modifications
Human serum albumin affinity characterization by analytical ultracentrifugation
Cryo-EM structure determination of semaglutide-bound GLP-1R-Gs protein complexes
Comparative receptor-engagement and conformational dynamics studies with other GLP-1 analogues