Compound Overview

GLP2-T is a synthetic 39-amino-acid modified peptide with two _-aminoisobutyric acid residues in the peptide backbone. The molecule is a lysine-20-conjugated fatty-acid-modified dual GIPR/GLP-1R ligand bearing a C20 diacid side chain.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including receptor pharmacology studies, cell-based signaling assays, structural biology workflows, and analytical method development involving tirzepatide.

Molecular Information

Compound Type: Modified peptide
Sequence: Y-Aib-E-G-T-F-T-S-D-Y-S-I-Aib-L-D-K-I-A-Q-K-A-F-V-Q-W-L-I-A-G-G-P-S-S-G-A-P-P-P-S
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: 4813.45 g/mol
CAS Number: 2023788-19-2
Purity: 98.90%

Research Applications

Tirzepatide is used in laboratory research to examine dual incretin receptor pharmacology, ligand-receptor binding geometry, and downstream signaling behavior. Published studies have employed tirzepatide in cryo-EM structural analysis of GIPR- and GLP-1R-bound complexes, cell-based cAMP response experiments, signaling bias comparisons, and LC/MS workflows for quantitation and impurity characterization.

Dual GIPR/GLP-1R receptor activation studies
Cell-based cAMP signaling assays
Cryo-EM characterization of tirzepatide-GIPR complexes
Cryo-EM characterization of tirzepatide-GLP-1R complexes
Comparative signaling bias studies versus native incretin peptides
LC/MS quantitation and impurity profiling of tirzepatide