Compound Overview

GLP3-R is a synthetic lipidated peptide described as a triple peptidic agonist of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Public compound and pharmacology records identify it as a single-molecule modified peptide incorporating noncanonical amino acid residues and a C20 diacid-containing side chain.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including cell-based receptor activation assays and in vitro signaling studies involving GCGR, GIPR, and GLP-1R.

Molecular Information

Compound Type: Lipidated peptide
Sequence: H-Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-αMeLeu-Leu-Asp-Lys-Lys(AEEA-γGlu-eicosanedioic acid)-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight: 4731.33 g/mol
CAS Number: 2381089-83-2
Purity: 99.80%

Research Applications

Published pharmacology and structural studies place retatrutide in compound-specific research workflows focused on triple-receptor ligand characterization. Reported work includes in vitro receptor activation, potency comparison across GCGR, GIPR, and GLP-1R, signaling readouts such as cAMP accumulation, and structural evaluation of multimodal class B GPCR engagement.

Cell-based GLP-1R agonist activity assays
Cell-based GIPR agonist activity assays
Cell-based GCGR agonist activity assays
Comparative potency profiling versus native peptide ligands
In vitro cAMP signaling studies across class B GPCR targets
Structural studies of triple-receptor peptide engagement