Compound Overview

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. In published literature, it is described as an ACTH-derived peptide analogue containing the ACTH(4-7) motif with a C-terminal Pro-Gly-Pro segment.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including serum peptidase studies, biochemical enzyme assays, transcriptomic analyses, and artificial membrane model systems.

Molecular Information

Compound Type: Synthetic heptapeptide
Sequence: MEHFPGP
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 813.93 g/mol
CAS Number: 80714-61-0
Purity: 99.20%

Research Applications

Published studies have used Semax in compound-specific investigations of peptide degradation in serum, inhibition of enkephalin-degrading activity, gene-expression responses in neural tissue models, and copper-associated peptide interaction studies in artificial membrane systems.

High-performance liquid chromatography studies of Semax degradation in rat blood and serum
Serum peptidase inhibitor experiments used to characterize Semax cleavage pathways
Enzyme assays assessing inhibition of enkephalin-degrading activity in human serum
Gene-expression studies examining intracellular signaling pathway transcripts after Semax exposure
Studies of BDNF/TrkB-system expression and activation in rat hippocampal tissue
Biophysical studies of copper-associated peptide aggregation in artificial membrane models