Compound Overview

Sermorelin is a synthetically produced 29-amino-acid peptide corresponding to the amino-terminal 1-29 segment of human growth hormone-releasing hormone. The peptide is C-terminally amidated.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including receptor-binding assay development, peptide analytical characterization, and LC-HRMS/MS method development.

Molecular Information

Compound Type: Synthetic peptide
Sequence: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight: 3,357.90
CAS Number: 86168-78-7
Purity: 99.20%

Research Applications

Published research involving Sermorelin includes receptor-binding and structure-affinity investigations of GHRH/GRF analogues, along with analytical workflows for detecting Sermorelin and its metabolites by high-resolution mass spectrometry. Compound-specific studies also describe plasma incubation, metabolite identification, and urine-analysis methods that include Sermorelin as a target analyte.

Structure-affinity studies of Sermorelin in pituitary GRF receptor binding systems
Receptor-binding assay development for GRF(1-29) amide analog evaluation
Peptide stability assessment of Sermorelin in assay and plasma-incubation workflows
Immunoaffinity purification and LC-HRMS/MS identification of Sermorelin in plasma matrices
Metabolite profiling of Sermorelin, including characterization of GRF(3-29)
Nano-LC-Q/Orbitrap MS screening and confirmation methods targeting Sermorelin and its primary metabolite in urine matrices