Compound Overview

SS-31 is a synthetic Szeto-Schiller tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂. Published mechanistic studies describe SS-31 as a cardiolipin-binding, mitochondria-targeting peptide.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including lipid bilayer studies, isolated mitochondria assays, and cross-linking mass spectrometry workflows used to characterize SS-31 interactions in mitochondrial systems.

Molecular Information

Compound Type: Synthetic Szeto-Schiller tetrapeptide
Sequence: D-Arg-Dmt-Lys-Phe-NH₂
Molecular Formula: C₃₂H₄₉N₉O₅
Molecular Weight: 639.8
CAS Number: 736992-21-5
Purity: 99.10%

Research Applications

Compound-specific studies have used SS-31 to examine cardiolipin binding at the inner mitochondrial membrane, peptide effects on membrane surface electrostatics and lipid packing, cytochrome c/cardiolipin interactions, and mitochondrial protein interaction networks.

Cardiolipin-binding studies in model lipid bilayers and mitochondrial membranes
Membrane surface electrostatics and lipid packing experiments
Cytochrome c/cardiolipin interaction and peroxidase activity assays
Mitochondrial cristae and respiratory supercomplex organization studies
Oxidative phosphorylation and ATP-synthesis measurements in isolated mitochondria
Chemical cross-linking mass spectrometry for SS-31 mitochondrial interactome mapping