Compound Overview

Survodutide is a 29-amino-acid acylated peptide built on a modified glucagon sequence and incorporating 1-aminocyclobutane-1-carboxylic acid, a glycine-serine linker, and a C18 di-acid moiety. It is characterized as a dual glucagon receptor and glucagon-like peptide-1 receptor agonist.

This material is supplied as a laboratory research reagent intended for controlled experimental environments such as cell-based receptor assays, ex vivo bioactivity assays, and isolated pancreatic islet studies.

Molecular Information

Compound Type: Acylated peptide
Sequence: H-Ac4c-QGTFTSDYSKYLDERAAKDFI-X-WLESA-NH2 where Ac4c = 1-Aminocyclobutane-1-carboxylic Acid and X = a glycine-serine linker carrying a C18 di-acid
Molecular Formula: C₁₉₂H₂₈₉N₄₇O₆₁
Molecular Weight: 4,231.7 g/mol
CAS Number: 2805997-46-8
Purity: 99.50%
Appearance: Lyophilized Powder
Storage: -20�C

Research Applications

Published compound-specific characterization places survodutide in receptor pharmacology and mechanism studies focused on balanced GCGR/GLP-1R agonism, including cell-based functional assays, endogenous receptor systems, ex vivo bioactivity workflows, and isolated pancreatic islet testing.

Functional agonism studies at glucagon receptor and glucagon-like peptide-1 receptor targets
cAMP reporter assays in CHO-K1 cells expressing GLP-1R or GCGR
Endogenous receptor activity studies in MIN6 cells
Primary hepatocyte assay workflows for GCGR-linked activity
Ex vivo bioactivity assay development and correlation studies
Glucose-stimulated insulin secretion studies in isolated mouse, rat, and perifused human pancreatic islets