Compound Overview

TB-500 is a synthetic heptapeptide identified in the literature as the N-terminal acetylated 17-23 fragment of thymosin beta 4, corresponding to Ac-LKKTETQ. Published analytical work distinguishes TB-500 from full-length thymosin beta 4 and characterizes it as an acetylated fragment rather than the native 43-amino-acid peptide.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including analytical method development, reference standard work, and in vitro metabolism studies.

Molecular Information

Compound Type: Synthetic heptapeptide
Sequence: LKKTETQ
Molecular Formula: C₃₈H₆₈N₁₀O₁₄
Molecular Weight: 889.0 g/mol
CAS Number: 885340-08-9
Purity: 99.90%

Research Applications

Published compound-specific research on TB-500 is centered on analytical chemistry, structural characterization, and metabolism profiling. Reported studies describe synthesis and high-resolution mass spectrometric characterization of Ac-LKKTETQ, targeted detection of the parent peptide and its metabolites, and quantitative analysis in controlled in vitro systems and biological matrices.

Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified as Ac-LKKTETQ
High-performance liquid chromatography and high-resolution mass spectrometric identification of TB-500
Liquid chromatography-mass spectrometry detection of TB-500 and related metabolites in plasma and urine matrices
UHPLC-Q-Exactive Orbitrap MS/MS quantification of TB-500 and structurally identified metabolites
In vitro metabolism profiling of TB-500 in serum and enzyme-system experiments
Use of synthesized authentic standards for structural identification of TB-500 metabolites