Compound Overview

Tesamorelin is a synthetic peptide analog of human growth hormone-releasing factor prepared as the acetate salt. Its structure comprises the 44-amino-acid human GRF sequence with an N-terminal hexenoyl modification.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including receptor-binding assays, bioidentity testing, peptide impurity profiling, and chromatographic-mass spectrometric method development.

Molecular Information

Compound Type: Synthetic peptide analog of human growth hormone-releasing factor
Sequence: Hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S • x C₂H₄O₂ (x ≈ 7)
Molecular Weight: 5135.9 Da (free base equivalent)
CAS Number: 901758-09-6
Purity: 99.30%
Salt Form: Acetate
Analytical Method: HPLC identification and impurity profiling; mass spectral analysis; peptide mapping

Research Applications

Tesamorelin is documented in compound-specific receptor pharmacology, bioidentity assessment, reference standard characterization, impurity profiling, and chromatographic-mass spectrometric detection workflows. Published analytical studies also describe tesamorelin in plasma- and urine-based detection and metabolism investigations within larger GHRH analog panels.

Human GRF receptor binding and stimulation assays
Comparative in vitro potency assessment relative to endogenous GRF
Bioidentity testing of tesamorelin drug substance activity
Primary reference standard development and characterization
HPLC-based identity, acetate-content, and peptide-impurity profiling
Immunoaffinity and LC-MS-based detection workflows for tesamorelin in plasma and urine