Compound Overview

Thymosin Alpha 1 (TA1) is an N-terminal acetylated 28-amino-acid peptide. The verified free-base peptide sequence is Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN.

This material is supplied as a laboratory research reagent intended for controlled experimental environments, including chromatographic characterization, mass-spectrometric sequence confirmation, and structural studies in membrane-mimetic systems.

Molecular Information

Compound Type: N-terminal acetylated 28-amino-acid peptide
Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Weight: 3108.3 g/mol
CAS Number: 62304-98-7
Purity: 99.70%
Appearance: White to off-white lyophilized powder
Solubility: Water, up to 2 mg/mL
Storage: Store below -18°C

Research Applications

Published compound-specific studies on Thymosin Alpha 1 include primary-structure confirmation, N-terminal acetylation analysis, reverse-phase HPLC and mass-spectrometric characterization, recombinant generation from prothymosin alpha precursors, and conformational analysis in mixed-solvent, micellar, and phospholipid membrane models.

Primary-structure confirmation and sequence analysis of the 28-residue peptide
Reverse-phase HPLC and tandem mass spectrometry characterization of N-terminally acetylated TA1 preparations
Recombinant generation of N-terminally acetylated TA1 from prothymosin alpha by legumain cleavage followed by chromatographic purification
NMR conformational analysis in water/2,2,2-trifluoroethanol solvent mixtures
NMR and circular dichroism studies of TA1 folding and insertion in sodium dodecyl sulfate micelles
Interaction studies with phosphatidylcholine/phosphatidylserine membrane models and human serum albumin